SCHEMBL2371992

SCHEMBL2371992

[CH2]NS(=O)(=O)c1ccc(Cl)c2ncccc12

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FTO Q9C0B1 2/20 0.50
SLC40A1 Q9NP59 6/20 0.49
ALDH1A1 P00352 4/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
KDM4E B2RXH2 4/20 0.47
HPGD P15428 1/20 0.46
COMT P21964 2/20 0.44
POLB P06746 1/20 0.44
CYP1A2 P05177 1/20 0.42
ALOX15 P16050 1/20 0.42
HIF1A Q16665 1/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9200741 0.80 KDM4E (0.52) FTOSLC40A1ALDH1A1MEN1KMT2A
SCHEMBL15461570 0.80 COMT (0.49) FTOSLC40A1ALDH1A1KDM4ECOMT
SCHEMBL9198856 0.80 COMT (0.69) FTOSLC40A1ALDH1A1MEN1KMT2A
SCHEMBL9198904 0.76 KDM4E (0.48) FTOSLC40A1ALDH1A1KDM4EHPGD
SCHEMBL196536 0.72 KDM4E (0.70) SLC40A1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL9198579 0.72 KMT2A (0.59) SLC40A1ALDH1A1KMT2AKDM4EHPGD
SCHEMBL2372160 0.71 MAPK1 (0.62) ALDH1A1MEN1KMT2AKDM4EPOLB
SCHEMBL19682809 0.71 KDM4E (0.54) FTOSLC40A1ALDH1A1MEN1KMT2A
SCHEMBL9397274 0.71 CYP3A4 (0.64) ALDH1A1MEN1KMT2AKDM4ECOMT
Hydrochloric Acid SCHEMBL17506546 0.70 KDM4E (0.53) FTOSLC40A1ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP claimed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US claimed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO claimed
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP disclosed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US disclosed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS STS, ARSA, TST FTO 3126/4885SLC40A1 2808/4885ALDH1A1 1980/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.