SCHEMBL2372370

SCHEMBL2372370

N#Cc1ccc(CN)cn1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 3/20 0.48
BRD4 O60885 1/20 0.36
CHEK1 O14757 4/20 0.36
GRM2 Q14416 2/20 0.36
HRH3 Q9Y5N1 1/20 0.36
NSD2 O96028 2/20 0.36
ADRB2 P07550 1/20 0.35
ALOX5AP P20292 1/20 0.35
FEN1 P39748 1/20 0.35
RRM2 P31350 1/20 0.35
AR P10275 1/20 0.35
EGLN2 Q96KS0 1/20 0.34
NSD3 Q9BZ95 1/20 0.34
NAMPT P43490 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL164139 0.98 LOXL2 (0.47) LOXL2BRD4CHEK1GRM2HRH3
Hydrochloric Acid SCHEMBL3176304 0.98 LOXL2 (0.47) LOXL2BRD4CHEK1GRM2HRH3
SCHEMBL3051067 0.84 CHRNA7 (0.41) LOXL2CHEK1GRM2
SCHEMBL21491789 0.79 BRD4 (0.38) LOXL2BRD4EGLN2
SCHEMBL24146512 0.79 GAA (0.38) BRD4CHEK1GRM2ALOX5APFEN1
SCHEMBL453184 0.79 BRD4 (0.39) BRD4CHEK1GRM2AREGLN2
SCHEMBL507109 0.79 AR (0.41) BRD4CHEK1GRM2ALOX5APFEN1
SCHEMBL2643631 0.79 BRD4 (0.36) BRD4CHEK1GRM2ALOX5APFEN1
SCHEMBL453185 0.79 CHEK1 (0.44) BRD4CHEK1GRM2AREGLN2
SCHEMBL452013 0.79 BRD4 (0.36) BRD4CHEK1GRM2NSD2ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3364967-B1 FERROPORTIN INHIBITORS VIFOR INT AG (CH) 2026-05-20 EP disclosed
US-20260124198-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS GILEAD SCIENCES INC (US) 2026-05-07 US disclosed
EP-4702028-A1 CRYSTALLINE PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITOR AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-03-04 EP disclosed
EP-4702023-A1 CRYSTALLINE PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITOR AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-03-04 EP disclosed
EP-4683919-A1 VANIN-1 INHIBITORS Athos Therapeutics, Inc. (US) 2026-01-28 EP disclosed
US-20260015349-A1 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF INSILICO MEDICINE IP LTD (CN) 2026-01-15 US disclosed
EP-3365339-B1 NOVEL FERROPORTIN INHIBITORS VIFOR INT AG (CH) 2025-07-16 EP disclosed
US-20250066353-A1 VANIN-1 INHIBITORS ATHOS THERAPEUTICS INC (US) 2025-02-27 US disclosed
US-20250034132-A1 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF INSILICO MEDICINE IP LIMITED (HK) 2025-01-30 US disclosed
US-12209101-B2 Prolyl hydroxylase domain-containing protein (PHD) inhibitors and uses thereof INSILICO MEDICINE IP LIMITED (HK) 2025-01-28 US disclosed
US-6444817-B1 ANTICOAGULANTS ABBOTT LABORATORIES 2002-09-03 US disclosed
WO-2002044145-A1 NEW MANDELIC ACID DERIVATIVES AND THEIR USE AS THROBIN INHIBITORS ASTRAZENECA AB (SE) 2002-06-06 WO disclosed
EP-1202988-A2 NOVEL INTEGRIN RECEPTOR ANTAGONISTS BASF AKTIENGESELLSCHAFT (DE) 2002-05-08 EP disclosed
WO-2001010847-A2 NOVEL INTEGRIN RECEPTOR ANTAGONISTS BASF AKTIENGESELLSCHAFT (DE) 2001-02-15 WO disclosed
US-6030972-A 2- OR 5-AMINOMETHYL,2- OR 5-CYANOPYRIMIDINES AS INTERMEDIATES OF ANTICOAGULANTS IN EXTRACORPOREAL CIRCULATION (HEART-LUNG MACHINE, HEMODIALYSIS) BASF AKTIENGESELLSCHAFT (DE) 2000-02-29 US disclosed
US-5932567-A Thrombin inhibitors BASF AKTIENGESELLSCHAFT (DE) 1999-08-03 US disclosed
EP-0809651-A1 THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1997-12-03 EP disclosed
EP-0773955-A1 NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE BASF AKTIENGESELLSCHAFT (DE) 1997-05-21 EP disclosed
WO-1996024609-A1 THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1996-08-15 WO disclosed
WO-1995035309-A1 NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE BASF AKTIENGESELLSCHAFT (DE) 1995-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260015349-A1 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF CBR1, HCCS, NCOR1 LOXL2 2776/4885BRD4 350/4885CHEK1 3669/4885
US-20250066353-A1 VANIN-1 INHIBITORS VCAM1, TMBIM6, VNN1 LOXL2 714/4885BRD4 85/4885CHEK1 1318/4885
US-20260124198-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS ZC3HAV1, CCR1, CCR6 LOXL2 2059/4885BRD4 615/4885CHEK1 323/4885
US-20250034132-A1 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS AND USES THEREOF EGLN3, EGLN2, EGLN1 LOXL2 698/4885BRD4 161/4885CHEK1 4537/4885
US-12209101-B2 Prolyl hydroxylase domain-containing protein (PHD) inhibitors and uses thereof EGLN2, EGLN3, EGLN1 LOXL2 1719/4885BRD4 480/4885CHEK1 3848/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.