Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 12/20 | 0.62 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | PTGFR | P43088 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372758 | 0.93 | DHODH (0.56) | DHODHPDE10APTGFRTSHR | |
| SCHEMBL2372609 | 0.91 | DHODH (0.53) | DHODHPDE10APTGFRKDM4E | |
| SCHEMBL2372797 | 0.89 | DHODH (0.66) | DHODHPDE10APTGFRTSHR | |
| SCHEMBL2373551 | 0.88 | DHODH (0.65) | DHODHPDE10APTGFRTSHR | |
| SCHEMBL2372825 | 0.87 | DHODH (0.64) | DHODHPDE10APTGFRTSHR | |
| SCHEMBL2373344 | 0.86 | DHODH (0.82) | DHODHPDE10APTGFRTSHR | |
| SCHEMBL2373047 | 0.85 | DHODH (0.54) | DHODHPDE10APTGFRTSHR | |
| SCHEMBL2373164 | 0.85 | DHODH (0.56) | DHODHPDE10APTGFRKDM4ETSHR | |
| SCHEMBL2373263 | 0.83 | TRPV4 (0.49) | DHODHPTGFRKDM4E | |
| SCHEMBL2372739 | 0.83 | DHODH (0.71) | DHODHPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |