Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PTGFR | P43088 | 5/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374017 | 0.93 | DHODH (0.45) | TRPV4NR1I2DHODHKDM4EGAA | |
| SCHEMBL2372609 | 0.93 | DHODH (0.53) | TRPV4NR1I2DHODHKDM4EGAA | |
| SCHEMBL2372758 | 0.90 | DHODH (0.56) | TRPV4NR1I2DHODHPTGFRTACR3 | |
| SCHEMBL2372822 | 0.90 | DHODH (0.49) | TRPV4DHODHKDM4EGAAPTGFR | |
| SCHEMBL2371969 | 0.90 | DHODH (0.44) | TRPV4NR1I2DHODHKDM4EGAA | |
| SCHEMBL2373287 | 0.89 | TRPV4 (0.52) | TRPV4NR1I2KDM4ETACR3MEN1 | |
| SCHEMBL2373266 | 0.85 | DHODH (0.47) | DHODHKDM4EGAAPTGFRMEN1 | |
| SCHEMBL2372676 | 0.85 | DHODH (0.49) | DHODHKDM4EGAAPTGFRMEN1 | |
| SCHEMBL2373099 | 0.84 | KDM4E (0.47) | DHODHKDM4EGAAPTGFRMEN1 | |
| SCHEMBL2373092 | 0.84 | KDM4E (0.56) | DHODHKDM4EGAAPTGFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |