⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30432879 | 0.90 | SSTR4 (0.32) | — | |
| SCHEMBL25172225 | 0.77 | DUT (0.32) | — | |
| SCHEMBL23726160 | 0.76 | KDM4E (0.34) | — | |
| SCHEMBL23725967 | 0.71 | MEN1 (0.34) | — | |
| SCHEMBL27030212 | 0.67 | METTL3 (0.38) | — | |
| SCHEMBL16096650 | 0.67 | DUT (0.36) | — | |
| SCHEMBL23725956 | 0.66 | KDM4E (0.50) | — | |
| SCHEMBL16095967 | 0.63 | — | — | |
| SCHEMBL23355597 | 0.63 | GRIN2D (0.36) | — | |
| SCHEMBL18076253 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |