SCHEMBL2372675

SCHEMBL2372675

COC(=O)c1ncccc1NCC(F)F

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.49
BRD4 O60885 1/20 0.47
KDM4E B2RXH2 5/20 0.41
ALDH1A1 P00352 2/20 0.41
ACLY P53396 1/20 0.39
KMT2A Q03164 1/20 0.38
POLB P06746 2/20 0.38
ALOX15 P16050 2/20 0.38
MAP2K1 Q02750 1/20 0.38
HTT P42858 1/20 0.38
SCD O00767 1/20 0.37
PARP1 P09874 1/20 0.37
ATM Q13315 1/20 0.37
HSD17B10 Q99714 1/20 0.37
LMNA P02545 2/20 0.37
TDP1 Q9NUW8 1/20 0.37
PKM P14618 2/20 0.36
BDKRB1 P46663 1/20 0.36
MAPK10 P53779 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2008273 0.80 L3MBTL1 (0.49) L3MBTL1BRD4KDM4EALDH1A1ACLY
SCHEMBL5258001 0.78 L3MBTL1 (0.50) L3MBTL1BRD4KDM4EALDH1A1ACLY
SCHEMBL5256090 0.78 L3MBTL1 (0.50) L3MBTL1BRD4KDM4EALDH1A1ACLY
SCHEMBL12296252 0.78 SCD (0.44) L3MBTL1KDM4EALDH1A1POLBALOX15
SCHEMBL1894761 0.77 L3MBTL1 (0.58) L3MBTL1BRD4KDM4EALDH1A1ACLY
SCHEMBL28035575 0.76 MKNK2 (0.39) L3MBTL1BRD4KDM4EALDH1A1KMT2A
SCHEMBL12411094 0.76 L3MBTL1 (0.54) L3MBTL1BRD4KDM4EALDH1A1ACLY
SCHEMBL12631173 0.74 SCD (0.45) KDM4EKMT2APOLBSCD
SCHEMBL28926009 0.74 L3MBTL1 (0.55) L3MBTL1BRD4KDM4EALDH1A1ACLY
SCHEMBL28751799 0.74 BRD4 (0.56) L3MBTL1BRD4KDM4EALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2550280-B1 PYRIDOTHIAZINES HAVING HERBICIDAL ACTION BASF SE (DE) 2014-02-26 EP disclosed
EP-2550280-B1 PYRIDOTHIAZINES HAVING HERBICIDAL ACTION BASF SE (DE) 2014-02-26 EP disclosed
US-8440594-B2 Pyridothiazines having herbicidal action BASF SE (DE) 2013-05-14 US disclosed
US-8440594-B2 Pyridothiazines having herbicidal action BASF SE (DE) 2013-05-14 US disclosed
US-8440594-B2 Pyridothiazines having herbicidal action BASF SE (DE) 2013-05-14 US disclosed
US-20130065760-A1 Substituted Pyridines Having Herbicidal Action BASF SE (DE) 2013-03-14 US disclosed
US-20130065760-A1 Substituted Pyridines Having Herbicidal Action BASF SE (DE) 2013-03-14 US disclosed
EP-2550280-A1 PYRIDOTHIAZINES HAVING HERBICIDAL ACTION BASF SE (DE) 2013-01-30 EP disclosed
US-20130005575-A1 Pyridothiazines Having Herbicidal Action BASF SE (DE) 2013-01-03 US disclosed
US-20130005575-A1 Pyridothiazines Having Herbicidal Action BASF SE (DE) 2013-01-03 US disclosed
US-20130005575-A1 Pyridothiazines Having Herbicidal Action BASF SE (DE) 2013-01-03 US disclosed
WO-2011117152-A1 PYRIDOTHIAZINES HAVING HERBICIDAL ACTION BASF SE (DE) 2011-09-29 WO disclosed
WO-2011117152-A1 PYRIDOTHIAZINES HAVING HERBICIDAL ACTION BASF SE (DE) 2011-09-29 WO disclosed
WO-2011117210-A1 SUBSTITUTED PYRIDINES HAVING HERBICIDAL ACTION BASF SE (DE) 2011-09-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130005575-A1 Pyridothiazines Having Herbicidal Action PNPO, PDXK, PLPBP L3MBTL1 3924/4885BRD4 2480/4885KDM4E 2111/4885
US-20130065760-A1 Substituted Pyridines Having Herbicidal Action PNPO, DDT, CYP4X1 L3MBTL1 4261/4885BRD4 2107/4885KDM4E 1043/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.