Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 15/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP11A1 | P05108 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10342095 | 0.81 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1CYP19A1CYP3A4CYP17A1 | |
| SCHEMBL2450572 | 0.81 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1CYP19A1CYP3A4CYP17A1 | |
| SCHEMBL11023995 | 0.79 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1CYP19A1TBXAS1LMNA | |
| SCHEMBL9107623 | 0.77 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1CYP19A1CYP3A4CYP17A1 | |
| SCHEMBL23727719 | 0.77 | NPSR1 (0.45) | ALDH1A1CYP3A4LMNA | |
| SCHEMBL214820 | 0.74 | OPRD1 (0.50) | ALDH1A1L3MBTL1CYP19A1LMNAGAA | |
| SCHEMBL5468463 | 0.73 | OPRM1 (0.41) | ALDH1A1L3MBTL1NFKB1LMNA | |
| SCHEMBL16357120 | 0.72 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1CYP19A1CYP3A4CYP17A1 | |
| SCHEMBL16786075 | 0.71 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1CYP19A1CYP3A4CYP17A1 | |
| SCHEMBL8503593 | 0.70 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| CN-115515934-A | NAMPT modulators | 赛特凯恩蒂克公司 | 2022-12-23 | — | — | CN | disclosed |
| EP-4100393-A1 | NAMPT MODULATORS | Cytokinetics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | ALDH1A1 2019/4885L3MBTL1 4152/4885CYP19A1 2895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.