Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404544 | 0.73 | ALDH1A1 (0.61) | ALDH1A1PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL31186675 | 0.73 | ALDH1A1 (0.61) | ALDH1A1PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL246244 | 0.71 | ALDH1A1 (0.53) | ALDH1A1PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL12047115 | 0.71 | SLC40A1 (0.51) | MEN1KMT2ANPC1POLBMAPT | |
| SCHEMBL20278424 | 0.70 | ALDH1A1 (0.49) | ALDH1A1PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL26235009 | 0.69 | ALDH1A1 (0.47) | ALDH1A1PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL29870301 | 0.69 | NPC1 (0.49) | ALDH1A1PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL5545370 | 0.67 | ALDH1A1 (0.53) | ALDH1A1PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL5542743 | 0.67 | ALDH1A1 (0.53) | ALDH1A1PDGFRBPDGFRAMEN1KMT2A | |
| SCHEMBL3344562 | 0.67 | CASP6 (0.62) | ALDH1A1PDGFRBPDGFRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3205650-B1 | EGFR INHIBITOR, AND PREPARATION AND APPLICATION THEREOF | SHANGHAI HANSOH BIOMEDICAL CO LTD (CN) | 2021-08-04 | — | — | EP | disclosed |