Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | PTGFR | P43088 | 12/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372172 | 0.95 | PLA2G2A (0.51) | DHODHPLA2G2APTGFRMITFAKR1C3 | |
| SCHEMBL2373029 | 0.93 | DHODH (0.57) | DHODHPLA2G2APTGFRMITF | |
| SCHEMBL2372795 | 0.89 | PTGFR (0.45) | DHODHPLA2G2APTGFRTRPV4KDM4E | |
| SCHEMBL2372251 | 0.88 | TRPV4 (0.51) | PLA2G2AAKR1C3AKR1C2TRPV4 | |
| SCHEMBL2373306 | 0.88 | DHODH (0.51) | DHODHPLA2G2APTGFRTRPV4KDM4E | |
| SCHEMBL2373573 | 0.86 | PTGFR (0.56) | DHODHPTGFR | |
| SCHEMBL2372609 | 0.85 | DHODH (0.53) | DHODHPTGFRTRPV4KDM4E | |
| SCHEMBL2372822 | 0.85 | DHODH (0.49) | DHODHPTGFRTRPV4KDM4E | |
| SCHEMBL2372797 | 0.85 | DHODH (0.66) | DHODHPTGFR | |
| SCHEMBL2372070 | 0.85 | DHODH (0.65) | DHODHPTGFRKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |