Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13004099 | 0.82 | ALDH1A1 (0.45) | SLC6A4HRH3TDP1MEN1KMT2A | |
| SCHEMBL16695140 | 0.80 | HRH3 (0.54) | HRH3SIGMAR1MEN1KMT2ALTA4H | |
| SCHEMBL19043081 | 0.75 | HRH3 (0.59) | HRH3SIGMAR1MEN1KMT2ALTA4H | |
| SCHEMBL23732064 | 0.74 | HTR1A (0.44) | HRH3MEN1KMT2ALTA4HALDH1A1 | |
| SCHEMBL2891302 | 0.74 | ACACB (0.41) | ALDH1A1 | |
| SCHEMBL16695099 | 0.74 | CSNK2A1 (0.54) | SLC6A4SLC6A3HRH3SIGMAR1LTA4H | |
| SCHEMBL16453525 | 0.72 | NOS3 (0.48) | MEN1KMT2ACYP1A2 | |
| SCHEMBL30786159 | 0.71 | DRD2 (0.48) | DRD2SLC6A4SLC6A3HRH3SIGMAR1 | |
| SCHEMBL21608303 | 0.71 | CXCR4 (0.49) | SIGMAR1 | |
| SCHEMBL25781852 | 0.71 | HRH3 (0.52) | DRD2SLC6A4SLC6A3HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3912977-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BioMarin Pharmaceutical Inc. (US) | 2021-11-24 | — | — | EP | disclosed |
| EP-3046920-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARM INC (US) | 2021-08-04 | — | — | EP | disclosed |