Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | POR | P16435 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138945 | 0.83 | RAPGEF4 (0.42) | RAPGEF4ALDH1A1TSHRCASP1CASP7 | |
| SCHEMBL15965543 | 0.82 | L3MBTL1 (0.42) | RAPGEF4ALDH1A1TSHRCASP1CASP7 | |
| SCHEMBL30236538 | 0.80 | RAPGEF4 (0.44) | RAPGEF4ALDH1A1TSHRCASP1CASP7 | |
| Methylamine SCHEMBL28132703 | 0.80 | RAPGEF4 (0.41) | RAPGEF4TSHRCASP1CASP7SMN1; SMN2 | |
| SCHEMBL1607815 | 0.80 | RAPGEF4 (0.44) | RAPGEF4ALDH1A1TSHRCASP1CASP7 | |
| SCHEMBL1559677 | 0.80 | KDM4E (0.45) | RAPGEF4ALDH1A1TSHRCASP1CASP7 | |
| SCHEMBL11541207 | 0.80 | ALDH1A1 (0.40) | TRPV4ALDH1A1TSHRSMN1; SMN2LMNA | |
| SCHEMBL30069489 | 0.80 | KDM4E (0.45) | RAPGEF4ALDH1A1TSHRCASP1CASP7 | |
| SCHEMBL29627448 | 0.79 | TRPV4 (0.42) | TRPV4ALDH1A1TSHRSMN1; SMN2KDM4E | |
| SCHEMBL2426442 | 0.79 | TRPV4 (0.42) | TRPV4ALDH1A1TSHRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362448-B1 | NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA | INVENTIVA (FR) | 2021-08-04 | — | — | EP | disclosed |