Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 5/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22231128 | 0.77 | CTH (0.40) | KCNH2HTR1ADRD2DRD4SMN1; SMN2 | |
| SCHEMBL21703346 | 0.76 | HTR1A (0.39) | KCNH2HTR1ADRD2DRD4SMN1; SMN2 | |
| SCHEMBL2369715 | 0.76 | HTR1A (0.39) | KCNH2HTR1ADRD2DRD4SMN1; SMN2 | |
| SCHEMBL28271183 | 0.75 | KCNH2 (0.43) | KCNH2HTR1ADRD2DRD4SMN1; SMN2 | |
| SCHEMBL7929143 | 0.74 | CHRNB2 (0.39) | KCNH2HTR1ADRD2DRD4SMN1; SMN2 | |
| SCHEMBL31053494 | 0.71 | HDAC8 (0.54) | KCNH2HTR1ADRD2DRD4GSK3B | |
| SCHEMBL27410245 | 0.71 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2AEPHX2CCR5 | |
| SCHEMBL18313483 | 0.70 | GNAI3 (0.37) | KCNH2HTR1ADRD2DRD4SMN1; SMN2 | |
| SCHEMBL15024277 | 0.70 | EPHX2 (0.35) | KCNH2HTR1ADRD2DRD4GSK3B | |
| SCHEMBL22431439 | 0.69 | EPHX2 (0.37) | KCNH2HTR1ADRD2DRD4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238183-A1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AS PROTEIN KINASE INHIBITORS | SUMITOMO PHARMA AMERICA, INC. | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238183-A1 | SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AS PROTEIN KINASE INHIBITORS | PIM1, PIM2, PIM3 | KCNH2 1832/4885HTR1A 3419/4885DRD2 4770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.