Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735588 | 1.00 | HTT (0.51) | HTTL3MBTL1HPGDKMT2AMEN1 | |
| SCHEMBL12442701 | 0.85 | GPR183 (0.55) | HTTL3MBTL1HPGDMGLLHSD11B1 | |
| SCHEMBL22735458 | 0.84 | HCRTR1 (0.48) | KMT2AMEN1EPHX2HRH3 | |
| SCHEMBL22735357 | 0.84 | RXFP1 (0.49) | HTTL3MBTL1HPGDKMT2AMEN1 | |
| SCHEMBL23716678 | 0.84 | SPR (0.48) | KMT2AMEN1EPHX2HRH3OPRM1 | |
| SCHEMBL23734784 | 0.82 | ALDH1A1 (0.51) | HTTKMT2AMGLLHSD11B1EPHX2 | |
| SCHEMBL12569639 | 0.82 | HTT (0.59) | HTTL3MBTL1HPGDKMT2AMEN1 | |
| SCHEMBL23734934 | 0.81 | MCHR1 (0.49) | HTTL3MBTL1HPGDMGLLHSD11B1 | |
| SCHEMBL2217297 | 0.81 | MGLL (0.58) | L3MBTL1HPGDKMT2AMEN1MGLL | |
| SCHEMBL2217300 | 0.81 | MGLL (0.58) | L3MBTL1HPGDKMT2AMEN1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3594202-B1 | SUBSTITUTED PYRROLIDINE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2021-08-11 | — | — | EP | disclosed |