Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 4/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1654680 | 0.90 | KDM4A (0.45) | KDM4AHDAC1ANO1GRM2NQO2 | |
| SCHEMBL27669311 | 0.84 | GRM2 (0.47) | KDM4AGRM2KCNA5RPS6KA1GPR119 | |
| SCHEMBL29555276 | 0.84 | KDM4A (0.43) | KDM4AGRM2NQO2KCNA5RPS6KA1 | |
| SCHEMBL23105713 | 0.84 | KDM4A (0.43) | KDM4AGRM2NQO2KCNA5RPS6KA1 | |
| SCHEMBL2443309 | 0.84 | GRM2 (0.44) | KDM4AHDAC1GRM2NQO2KCNA5 | |
| SCHEMBL12791296 | 0.84 | P2RX7 (0.46) | KDM4AHDAC1GRM2KCNA5RPS6KA1 | |
| SCHEMBL29952911 | 0.83 | KDM4A (0.42) | KDM4AGRM2NQO2KCNA5RPS6KA1 | |
| SCHEMBL29076078 | 0.83 | KCNQ4 (0.47) | KDM4AHDAC1GRM2KCNA5RPS6KA1 | |
| SCHEMBL4508520 | 0.83 | GPR119 (0.43) | KDM4AGRM2KCNA5RPS6KA1GPR119 | |
| SCHEMBL27669478 | 0.83 | GRM2 (0.43) | KDM4AGRM2NQO2KCNA5RPS6KA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464249-B1 | SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER (US) | 2021-08-11 | — | — | EP | disclosed |