Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28044155 | 0.86 | GABRA1 (0.39) | L3MBTL1SMN1; SMN2LMNAGABRA1GABRB2 | |
| SCHEMBL15417412 | 0.84 | TSHR (0.38) | L3MBTL1SMN1; SMN2GABRA1GABRB2TSHR | |
| SCHEMBL807524 | 0.82 | TSHR (0.46) | L3MBTL1SMN1; SMN2KDM5ATSHRLRRK2 | |
| SCHEMBL9734348 | 0.80 | GABRA1 (0.50) | L3MBTL1SMN1; SMN2LMNAGABRA1GABRB2 | |
| SCHEMBL21736887 | 0.78 | HTR2A (0.34) | SMN1; SMN2KDM5ATSHRLRRK2MAPK1 | |
| SCHEMBL21728161 | 0.77 | DRD2 (0.32) | TSHRSLC6A2SLC6A4 | |
| SCHEMBL106062 | 0.76 | TSHR (0.50) | L3MBTL1SMN1; SMN2GABRA1GABRB2TSHR | |
| SCHEMBL13778070 | 0.75 | TSHR (0.43) | L3MBTL1SMN1; SMN2LMNAGABRA1GABRB2 | |
| SCHEMBL7790350 | 0.75 | GABRA1 (0.41) | LMNAGABRA1GABRB2KDM5ATSHR | |
| SCHEMBL13377164 | 0.75 | GABRA1 (0.41) | L3MBTL1SMN1; SMN2LMNAGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814331-B1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | ORSOBIO INC (US) | 2023-06-14 | — | — | EP | disclosed |
| EP-3558955-B1 | BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-B]PYRIDINE, QUINAZOLINE, PHTHALAZINE, PYRIDO[2,3-D]PYRIDAZINE AND PYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC OR COLORECTAL CANCER | AMGEN INC (US) | 2021-08-11 | — | — | EP | disclosed |