Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23735874 | 0.86 | L3MBTL1 (0.38) | GABRA1GABRB2SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL27367559 | 0.77 | DYRK1A (0.40) | SMN1; SMN2LMNAL3MBTL1TSHRMEN1 | |
| SCHEMBL20611365 | 0.74 | L3MBTL1 (0.33) | SMN1; SMN2L3MBTL1TSHRARMAPK1 | |
| SCHEMBL27475655 | 0.74 | POLB (0.45) | SMN1; SMN2TSHRARCA1CA2 | |
| SCHEMBL3112611 | 0.73 | NOTUM (0.40) | SMN1; SMN2LMNAL3MBTL1MAPTMAPK1 | |
| SCHEMBL106062 | 0.73 | TSHR (0.50) | GABRA1GABRB2SMN1; SMN2L3MBTL1TSHR | |
| SCHEMBL27912602 | 0.72 | TDP1 (0.42) | SMN1; SMN2TSHRMAPTALDH1A1 | |
| SCHEMBL7790350 | 0.72 | GABRA1 (0.41) | GABRA1GABRB2LMNATSHRMAPT | |
| SCHEMBL11524213 | 0.72 | GABRA1 (0.41) | GABRA1GABRB2SMN1; SMN2TSHRAR | |
| SCHEMBL11967122 | 0.72 | TSHR (0.45) | GABRA1GABRB2L3MBTL1TSHRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105051044-A | Compounds and their use for modulating hemoglobin | GLOBAL BLOOD THERAPEUTICS INC | 2015-11-11 | — | — | CN | disclosed |