Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018111 | 0.86 | PAX8 (0.55) | PAX8TGM2BRD4CREBBPRAB9A | |
| SCHEMBL3261042 | 0.85 | CYP2A6 (0.48) | PAX8TGM2BRD4CREBBPRAB9A | |
| SCHEMBL31335398 | 0.82 | PAX8 (0.40) | PAX8TGM2BRD4CREBBPRAB9A | |
| SCHEMBL2641765 | 0.81 | PAX8 (0.49) | PAX8TGM2BRD4CREBBPRAB9A | |
| SCHEMBL470988 | 0.81 | PAX8 (0.44) | PAX8BRD4CREBBPRAB9AKDM4E | |
| SCHEMBL4031315 | 0.80 | HSD17B3 (0.45) | PAX8BRD4CREBBPMAPTMEN1 | |
| SCHEMBL4028881 | 0.80 | THRB (0.47) | PAX8RAB9ANPC1KDM4EMAPT | |
| SCHEMBL14384381 | 0.80 | PAX8 (0.50) | PAX8BRD4CREBBPRAB9AMAPT | |
| SCHEMBL3364970 | 0.80 | PAX8 (0.50) | PAX8BRD4CREBBPRAB9ANPSR1 | |
| SCHEMBL24448783 | 0.78 | NPSR1 (0.58) | PAX8BRD4CREBBPRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111499544-B | Synthetic method for preparing N-Boc-N-methyl-4-aminostyrene by one-pot method | 中国医学科学院放射医学研究所 | 2022-12-02 | — | — | CN | claimed |
| CN-111499544-A | Synthetic method for preparing N-Boc-N-methyl-4-aminostyrene by one-pot method | 中国医学科学院放射医学研究所 | 2020-08-07 | — | — | CN | claimed |
| CN-102526765-A | Abeta plaque developing agent and preparation method thereof | ZHENGZHOU TETRANOV PHARMACEUTICAL TECHNOLOGY CO LTD | 2012-07-04 | — | — | CN | claimed |
| CN-111499570-B | Synthesis method of AV-45 intermediate | 中国医学科学院放射医学研究所 | 2023-05-16 | — | — | CN | disclosed |
| CN-111499544-B | Synthetic method for preparing N-Boc-N-methyl-4-aminostyrene by one-pot method | 中国医学科学院放射医学研究所 | 2022-12-02 | — | — | CN | disclosed |
| CN-111499544-B | Synthetic method for preparing N-Boc-N-methyl-4-aminostyrene by one-pot method | 中国医学科学院放射医学研究所 | 2022-12-02 | — | — | CN | disclosed |
| CN-111499544-B | Synthetic method for preparing N-Boc-N-methyl-4-aminostyrene by one-pot method | 中国医学科学院放射医学研究所 | 2022-12-02 | — | — | CN | disclosed |
| CN-111499544-A | Synthetic method for preparing N-Boc-N-methyl-4-aminostyrene by one-pot method | 中国医学科学院放射医学研究所 | 2020-08-07 | — | — | CN | disclosed |
| CN-111499544-A | Synthetic method for preparing N-Boc-N-methyl-4-aminostyrene by one-pot method | 中国医学科学院放射医学研究所 | 2020-08-07 | — | — | CN | disclosed |
| CN-111499544-A | Synthetic method for preparing N-Boc-N-methyl-4-aminostyrene by one-pot method | 中国医学科学院放射医学研究所 | 2020-08-07 | — | — | CN | disclosed |
| CN-111499570-A | Synthetic method of AV-45 intermediate | 中国医学科学院放射医学研究所 | 2020-08-07 | — | — | CN | disclosed |
| CN-102526765-A | Abeta plaque developing agent and preparation method thereof | ZHENGZHOU TETRANOV PHARMACEUTICAL TECHNOLOGY CO LTD | 2012-07-04 | — | — | CN | disclosed |
| EP-1999109-B1 | STYRYLPYRIDINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2011-12-28 | — | — | EP | disclosed |
| EP-2363391-A1 | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques | The Trustees of The University of Pennsylvania (US) | 2011-09-07 | — | — | EP | disclosed |
| EP-2363392-A1 | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques | The Trustees of The University of Pennsylvania (US) | 2011-09-07 | — | — | EP | disclosed |
| US-7687052-B2 | radiolabeling; neurodegenerative diseases | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-03-30 | — | — | US | disclosed |
| US-20090123369-A1 | Styrylpyridine Derivatives and Their Use for Binding and Imaging Amyloid Plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-05-14 | — | — | US | disclosed |
| US-20080253967-A1 | Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-10-16 | — | — | US | disclosed |
| US-20080253967-A1 | Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-10-16 | — | — | US | disclosed |
| US-20080038195-A1 | radiolabeling; neurodegenerative diseases | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080253967-A1 | Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques | APP, APBA1, HSPBP1 | PAX8 2621/4885TGM2 2249/4885BRD4 483/4885 |
| US-20080038195-A1 | radiolabeling; neurodegenerative diseases | APP, PSEN1, HTT | PAX8 4795/4885TGM2 1392/4885BRD4 460/4885 |
| US-20090123369-A1 | Styrylpyridine Derivatives and Their Use for Binding and Imaging Amyloid Plaques | APP, APBA1, PSEN1 | PAX8 4418/4885TGM2 1683/4885BRD4 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.