Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.36 |
| ▸ | ABAT | P80404 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,4,6-Trimethoxybenzaldehyde SCHEMBL34873 | 0.85 | ERN1 (0.74) | ERN1LMNAALDH1A1PRKDCABCG2 | |
| 2,4,6-Trimethoxybenzaldehyde SCHEMBL28687257 | 0.83 | ERN1 (0.71) | ERN1LMNAALDH1A1PRKDCABCG2 | |
| SCHEMBL3818395 | 0.83 | ERN1 (0.60) | ERN1LMNAALDH1A1PRKDCABCG2 | |
| 2,4,6-Trimethoxybenzaldehyde SCHEMBL28687256 | 0.81 | ERN1 (0.75) | ERN1LMNAALDH1A1PRKDCABCG2 | |
| SCHEMBL1913197 | 0.76 | LMNA (0.54) | ERN1LMNAALDH1A1PRKDCTSHR | |
| SCHEMBL6093598 | 0.76 | ERN1 (0.53) | ERN1LMNAALDH1A1PRKDCABCG2 | |
| SCHEMBL13362398 | 0.76 | ALDH1A1 (0.59) | ERN1LMNAALDH1A1PRKDCTSHR | |
| SCHEMBL415683 | 0.76 | ERN1 (0.57) | ERN1LMNAALDH1A1PRKDCTSHR | |
| SCHEMBL439961 | 0.76 | ERN1 (0.52) | ERN1LMNAALDH1A1PRKDCTSHR | |
| SCHEMBL3181478 | 0.75 | ALDH1A1 (0.76) | LMNAALDH1A1TSHRTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7749940-B2 | Facilitated forward chemical genetics using tagged triazine library | NEW YORK UNIVERSITY (US) | 2010-07-06 | — | — | US | claimed |
| WO-2008130944-A1 | SOLID PHASE SYNTHESES OF AMINO PYRIMIDINE COMPOUNDS | IRM LLC (BM) | 2008-10-30 | — | — | WO | claimed |
| US-6949644-B2 | Methods for the synthesis of substituted purines | IRM LLC (BM) | 2005-09-27 | — | — | US | claimed |
| EP-1529048-A4 | METHODS FOR THE SYNTHESIS OF SUBSTITUTED PURINES | IRM LLC (BM) | 2005-09-14 | — | — | EP | claimed |
| EP-1529048-A2 | METHODS FOR THE SYNTHESIS OF SUBSTITUTED PURINES | IRM LLC (BM) | 2005-05-11 | — | — | EP | claimed |
| US-20030171583-A1 | Methods for the synthesis of substituted purines | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2003-09-11 | — | — | US | claimed |
| WO-2003031405-A2 | METHODS FOR THE SYNTHESIS OF SUBSTITUTED PURINES | IRM LLC (BM) | 2003-04-17 | — | — | WO | claimed |
| EP-4296270-A2 | A COMPOSITION COMPRISING STEM CELL CULTURES | The Scripps Research Institute (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3936508-B1 | A COMPOSITION COMPRISING STEM CELL CULTURES | SCRIPPS RESEARCH INST (US) | 2023-12-06 | — | — | EP | disclosed |
| EP-3936508-A1 | A COMPOSITION COMPRISING STEM CELL CULTURES | The Scripps Research Institute (US) | 2022-01-12 | — | — | EP | disclosed |
| US-20210403862-A1 | METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS | THE SCRIPPS RESEARCH INSTITUTE | 2021-12-30 | — | — | US | disclosed |
| EP-3623374-B1 | STEM CELL CULTURES | SCRIPPS RESEARCH INST (US) | 2021-09-08 | — | — | EP | disclosed |
| US-10975352-B2 | Methods of enhancing cell survival of stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-04-13 | — | — | US | disclosed |
| EP-1529048-A2 | METHODS FOR THE SYNTHESIS OF SUBSTITUTED PURINES | IRM LLC (BM) | 2005-05-11 | — | — | EP | disclosed |
| US-20050019831-A1 | Facilitated forward chemical genetics using tagged triazine library | NEW YORK UNIVERSITY (US) | 2005-01-27 | — | — | US | disclosed |
| WO-2004099106-A2 | FACILITATED FORWARD CHEMICAL GENETICS USING TAGGED TRIAZINE LIBRARY | NEW YORK UNIVERSITY (US) | 2004-11-18 | — | — | WO | disclosed |
| US-20030191312-A1 | Kinase inhibitor scaffolds and methods for their preparation | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2003-10-09 | — | — | US | disclosed |
| US-20030171583-A1 | Methods for the synthesis of substituted purines | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2003-09-11 | — | — | US | disclosed |
| WO-2003031405-A2 | METHODS FOR THE SYNTHESIS OF SUBSTITUTED PURINES | IRM LLC (BM) | 2003-04-17 | — | — | WO | disclosed |
| WO-2003031406-A2 | KINASE INHIBITOR SCAFFOLDS AND METHODS FOR THEIR PREPARATION | IRM LLC (BM) | 2003-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191312-A1 | Kinase inhibitor scaffolds and methods for their preparation | MAP2K2, MAP2K1, MAP2K7 | ERN1 451/4885LMNA 2078/4885ALDH1A1 3304/4885 |
| US-10975352-B2 | Methods of enhancing cell survival of stem cells | MCL1, BCL2, BCLAF1 | ERN1 2309/4885LMNA 656/4885ALDH1A1 429/4885 |
| US-20030171583-A1 | Methods for the synthesis of substituted purines | PNP, ATIC, NUDT1 | ERN1 1691/4885LMNA 1545/4885ALDH1A1 182/4885 |
| US-20210403862-A1 | METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS | MCL1, BCL2, BCLAF1 | ERN1 2309/4885LMNA 656/4885ALDH1A1 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.