Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739531 | 0.89 | MTNR1A (0.39) | MTNR1A | |
| SCHEMBL22521009 | 0.88 | MTNR1A (0.39) | MTNR1A | |
| SCHEMBL24830149 | 0.88 | MTNR1A (0.32) | MTNR1A | |
| SCHEMBL24830076 | 0.88 | MTNR1A (0.37) | MTNR1AKDM4E | |
| SCHEMBL22788944 | 0.85 | KDM4E (0.33) | GAAKDM4EALOX15 | |
| SCHEMBL22359302 | 0.84 | MTNR1A (0.33) | MTNR1AGAA | |
| SCHEMBL24159937 | 0.84 | ALDH1A1 (0.32) | GAAALDH1A1KDM4EALOX15 | |
| SCHEMBL23739734 | 0.83 | NR1H2 (0.32) | — | |
| SCHEMBL24160595 | 0.82 | KDM4E (0.34) | GAAKDM4EALOX15 | |
| SCHEMBL22521042 | 0.82 | VHL (0.32) | GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |