Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739905 | 0.92 | DRD2 (0.45) | DRD4DRD2CACNA1G | |
| SCHEMBL23739920 | 0.92 | HTR1A (0.42) | DRD4DRD2MEN1MAPTHTT | |
| SCHEMBL23739670 | 0.92 | DRD2 (0.42) | DRD4DRD2SLC6A4ADRA1DADRA1A | |
| SCHEMBL23739676 | 0.91 | HTR1A (0.44) | KDM4EDRD4DRD2ADRA1DADRA1A | |
| SCHEMBL23739575 | 0.90 | HTR1A (0.39) | LMNAMAPK1DRD4DRD2SMN1; SMN2 | |
| SCHEMBL23739779 | 0.90 | ADRA1D (0.39) | ADRA1DADRA1AADRA1B | |
| SCHEMBL23739430 | 0.90 | ADRA1B (0.40) | DRD4DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL23739535 | 0.89 | DRD2 (0.42) | DRD4DRD2SLC6A4 | |
| SCHEMBL23739716 | 0.89 | KCNH2 (0.43) | DRD4DRD2 | |
| SCHEMBL23739929 | 0.89 | DRD2 (0.43) | DRD4DRD2CACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |