Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | DRD3 | P35462 | 7/20 | 0.48 |
| ▸ | HTR7 | P34969 | 10/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739648 | 0.99 | DRD2 (0.47) | DRD2DRD3HTR7HTR1AALDH1A1 | |
| SCHEMBL23739921 | 0.90 | DRD2 (0.41) | DRD2DRD3HTR7HTR1AADRA1D | |
| SCHEMBL23739671 | 0.90 | ADRA1B (0.40) | DRD2DRD3HTR7HTR1AALDH1A1 | |
| SCHEMBL23739541 | 0.89 | HTR1A (0.39) | DRD2DRD3HTR7HTR1AALDH1A1 | |
| SCHEMBL23739726 | 0.88 | DRD2 (0.46) | DRD2DRD3HTR7HTR1AALDH1A1 | |
| SCHEMBL23739676 | 0.88 | HTR1A (0.44) | DRD2DRD3HTR7HTR1AALDH1A1 | |
| SCHEMBL23739920 | 0.87 | HTR1A (0.42) | DRD2DRD3HTR7HTR1AALDH1A1 | |
| SCHEMBL23739430 | 0.86 | ADRA1B (0.40) | DRD2DRD3HTR7HTR1AADRA1D | |
| SCHEMBL23739600 | 0.86 | KDM4E (0.40) | DRD2MEN1CYP3A4CYP2D6ADRA1D | |
| SCHEMBL23739903 | 0.85 | DRD3 (0.37) | DRD2DRD3HTR7DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |