Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.37 |
| ▸ | HTR1A | P08908 | 6/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | HTR7 | P34969 | 4/20 | 0.37 |
| ▸ | HTR6 | P50406 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739929 | 0.94 | DRD2 (0.43) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL23739905 | 0.93 | DRD2 (0.45) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL23739508 | 0.93 | DRD2 (0.37) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL23739920 | 0.92 | HTR1A (0.42) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL23739535 | 0.91 | DRD2 (0.42) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL23740034 | 0.90 | HTR1A (0.36) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL23739903 | 0.90 | DRD3 (0.37) | DRD2HTR2AHTR7DRD4DRD3 | |
| SCHEMBL23739716 | 0.90 | KCNH2 (0.43) | DRD2HTR1AHTR2AHTR7DRD4 | |
| SCHEMBL23739736 | 0.89 | HTR1A (0.37) | DRD2HTR1AHTR2AHTR7DRD4 | |
| SCHEMBL23739600 | 0.89 | KDM4E (0.40) | DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |