Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 8/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23740034 | 0.99 | HTR1A (0.36) | HTR1AADRA1BADRA1AHTR7DRD2 | |
| SCHEMBL23739903 | 0.95 | DRD3 (0.37) | HTR7DRD2HTR2ADRD3DRD4 | |
| SCHEMBL23739921 | 0.93 | DRD2 (0.41) | HTR1AADRA1BADRA1AHTR7DRD2 | |
| SCHEMBL23739929 | 0.91 | DRD2 (0.43) | HTR1AHTR7DRD2HTR2ACACNA1G | |
| SCHEMBL23739905 | 0.90 | DRD2 (0.45) | HTR1AHTR7DRD2HTR2ACACNA1G | |
| SCHEMBL23739535 | 0.89 | DRD2 (0.42) | HTR1AHTR7DRD2HTR2ADRD3 | |
| SCHEMBL23739669 | 0.89 | DRD2 (0.37) | HTR1AHTR7DRD2HTR2ADRD3 | |
| SCHEMBL23739671 | 0.87 | ADRA1B (0.40) | HTR1AADRA1BADRA1AHTR7DRD2 | |
| SCHEMBL23739430 | 0.86 | ADRA1B (0.40) | HTR1AADRA1BADRA1AHTR7DRD2 | |
| SCHEMBL23739541 | 0.85 | HTR1A (0.39) | HTR1AADRA1BADRA1AHTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |