Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739751 | 0.86 | DRD2 (0.41) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL23739743 | 0.79 | HTR2A (0.33) | HTR2AABCB1 | |
| SCHEMBL23739846 | 0.78 | ALDH1A1 (0.35) | DRD2ABCB1 | |
| SCHEMBL23739663 | 0.75 | MAPT (0.48) | HTR1AHTR7 | |
| SCHEMBL23739761 | 0.75 | DRD3 (0.40) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL23740080 | 0.75 | HTR1A (0.48) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL23739718 | 0.74 | ADAMTS5 (0.39) | HTR1ADRD2HTR2A | |
| SCHEMBL23739848 | 0.73 | DRD2 (0.52) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL23739613 | 0.73 | ADRA1D (0.43) | HTR1A | |
| SCHEMBL23739773 | 0.73 | HTR1A (0.41) | HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |