Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739718 | 0.87 | ADAMTS5 (0.39) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL23739756 | 0.87 | MAPT (0.44) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL23739743 | 0.81 | HTR2A (0.33) | MAPTSMN1; SMN2KMT2AMEN1HTT | |
| SCHEMBL23739841 | 0.80 | MAPT (0.53) | MAPTSMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL23739437 | 0.77 | DRD2 (0.42) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL23739693 | 0.75 | HTR1A (0.44) | HTR1AHTR7 | |
| SCHEMBL23739741 | 0.74 | ALDH1A1 (0.32) | MAPTSMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL23739489 | 0.74 | NPC1 (0.43) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL23740007 | 0.74 | MAPT (0.34) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL24818019 | 0.73 | S1PR5 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |