Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 16/20 | 0.33 |
| ▸ | HTR1A | P08908 | 4/20 | 0.33 |
| ▸ | HTR6 | P50406 | 4/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | HTR1D | P28221 | 2/20 | 0.30 |
| ▸ | HTR1B | P28222 | 2/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | HTR5A | P47898 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23739587 | 0.87 | DRD2 (0.43) | HTR7HTR1AHTR6DRD2HTR2A | |
| SCHEMBL23739439 | 0.85 | DRD2 (0.47) | HTR7HTR1AHTR6DRD2HTR2A | |
| SCHEMBL23739915 | 0.84 | DRD3 (0.39) | HTR7HTR1AHTR6DRD2HTR1D | |
| SCHEMBL23739586 | 0.84 | DRD2 (0.47) | HTR7HTR1AHTR6DRD2HTR2A | |
| SCHEMBL23739573 | 0.83 | HTR1A (0.30) | HTR7HTR1A | |
| SCHEMBL23739531 | 0.83 | MTNR1A (0.39) | MTNR1A | |
| SCHEMBL22521009 | 0.81 | MTNR1A (0.39) | MTNR1A | |
| SCHEMBL24830076 | 0.81 | MTNR1A (0.37) | MTNR1A | |
| SCHEMBL23739482 | 0.80 | MTNR1A (0.34) | DRD2MTNR1A | |
| SCHEMBL23739966 | 0.79 | KDM4E (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3862348-A1 | ISOINDOLINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-08-11 | — | — | EP | disclosed |