Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.51 |
| ▸ | WNT1 | P04628 | 8/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 4/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | CDK7 | P50613 | 4/20 | 0.39 |
| ▸ | CCNH | P51946 | 4/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.39 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20938540 | 0.76 | DYRK1A (0.43) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL23740951 | 0.76 | GSK3B (0.59) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL23740979 | 0.74 | GSK3B (0.58) | GSK3BDYRK1AWNT1 | |
| SCHEMBL24219536 | 0.73 | DYRK1A (0.53) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL23048907 | 0.72 | DYRK1A (0.64) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL23741126 | 0.72 | DYRK1A (0.56) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL19546936 | 0.71 | HCAR3 (0.33) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL23916298 | 0.71 | DYRK1A (0.42) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL23741168 | 0.70 | GSK3B (0.61) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL20414845 | 0.70 | GSK3B (0.61) | GSK3BDYRK1AWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |