Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23747295 | 0.85 | L3MBTL1 (0.47) | MAPK1KDM4EHTTSMN1; SMN2NPC1 | |
| SCHEMBL20851535 | 0.75 | NOS3 (0.42) | MAPK1KDM4ESMN1; SMN2NPC1L3MBTL1 | |
| SCHEMBL5456877 | 0.74 | NPC1 (0.42) | MAPK1KDM4EHTTSMN1; SMN2NPC1 | |
| SCHEMBL19728695 | 0.73 | SMN1; SMN2 (0.65) | MAPK1KDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL19699507 | 0.73 | ALDH1A1 (0.51) | MAPK1KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL19699482 | 0.73 | ALDH1A1 (0.51) | MAPK1KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL10311686 | 0.73 | ALDH1A1 (0.51) | MAPK1KDM4EHTTALDH1A1NPC1 | |
| SCHEMBL19324095 | 0.73 | L3MBTL1 (0.45) | MAPK1KDM4EHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL3741239 | 0.73 | SMN1; SMN2 (0.42) | MAPK1KDM4EHTTSMN1; SMN2NPC1 | |
| SCHEMBL827728 | 0.72 | NOS3 (0.50) | KDM4EHTTNPC1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | MAPK1 846/4885KDM4E 2721/4885HTT 1174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.