Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23728137 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MGLLGRM1HTTSMN1; SMN2 | |
| SCHEMBL31229852 | 0.81 | MGLL (0.50) | ALDH1A1PKMFGFR1NOTUMMGLL | |
| SCHEMBL23749753 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MGLLGRM1ADRB1ACHE | |
| SCHEMBL23749752 | 0.77 | MGLL (0.41) | ALDH1A1FGFR1NOTUMMGLLGRM1 | |
| SCHEMBL23727071 | 0.75 | INMT (0.41) | ALDH1A1NOTUMSMN1; SMN2MAPTKDM4E | |
| SCHEMBL23727902 | 0.73 | ALDH1A1 (0.43) | ALDH1A1PKMNOTUMMGLLGRM1 | |
| SCHEMBL23727900 | 0.73 | ALDH1A1 (0.43) | ALDH1A1PKMNOTUMMGLLGRM1 | |
| SCHEMBL23749866 | 0.72 | PARP1 (0.44) | FGFR1MAPTMAPK1HSD17B10POLB | |
| SCHEMBL23749909 | 0.71 | SMN1; SMN2 (0.36) | SMN1; SMN2 | |
| SCHEMBL8139141 | 0.69 | NOTUM (0.51) | ALDH1A1PKMFGFR1NOTUMMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12617785-B2 | Pyrrolo[2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss | THE ROCKEFELLER UNIVERSITY (US) | 2026-05-05 | — | — | US | disclosed |
| EP-4100008-B1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | UNIV ROCKEFELLER (US) | 2025-04-02 | — | — | EP | disclosed |
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2023-05-04 | — | — | US | disclosed |
| CN-115515579-A | Pyrrolo [2,3-b ] pyridine-3-carboxamide compositions and methods for ameliorating hearing loss | 洛克菲勒大学 | 2022-12-23 | — | — | CN | disclosed |
| EP-4100008-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | The Rockefeller University (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158936-A1 | PYRROLO [2,3-B]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | THE ROCKEFELLER UNIVERSITY (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12617785-B2 | Pyrrolo[2,3-b]pyridine-3-carboxamide compositions and methods for ameliorating hearing loss | YAP1, LATS2, LATS1 | ALDH1A1 2546/4885PKM 1863/4885FGFR1 1114/4885 |
| US-20230137893-A1 | PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS | LATS2, LATS1, YAP1 | ALDH1A1 3775/4885PKM 897/4885FGFR1 1613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.