Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 8/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 2/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897222 | 0.93 | ALDH1A1 (0.44) | PIK3CBALDH1A1GLAPIK3CAOGA | |
| SCHEMBL7683991 | 0.91 | ALDH1A1 (0.43) | PIK3CBALDH1A1GLAPIK3CAOGA | |
| SCHEMBL5897067 | 0.83 | ALDH1A1 (0.43) | PIK3CBALDH1A1GLAPIK3CAOGA | |
| SCHEMBL5897076 | 0.83 | KDM4E (0.46) | ALDH1A1GLACYP2D6MAPTPOLB | |
| SCHEMBL5897648 | 0.83 | PIK3CB (0.40) | PIK3CBALDH1A1GLAPIK3CAPIK3CD | |
| SCHEMBL5897416 | 0.81 | KMT2A (0.39) | PIK3CBALDH1A1GLAPIK3CAOGA | |
| SCHEMBL5897116 | 0.80 | PIK3CB (0.37) | PIK3CBALDH1A1GLAPIK3CAPIK3CD | |
| SCHEMBL23750482 | 0.74 | KDM4E (0.50) | PIK3CBCXCR4ALDH1A1MAPTMEN1 | |
| SCHEMBL1089586 | 0.70 | CXCR4 (0.74) | PIK3CBCXCR4PIK3CAPIK3CDPIK3CG | |
| SCHEMBL7676555 | 0.69 | CYP1A2 (0.50) | CRHBPCRHR2CYP1A2CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432949-B1 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2002-08-13 | — | — | US | disclosed |