Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23758029 | 0.93 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL23757550 | 0.90 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL23756873 | 0.86 | ALDH1A1 (0.48) | ALDH1A1HSD17B10HPGDL3MBTL1GCK | |
| SCHEMBL4257305 | 0.85 | ALDH1A1 (0.56) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL13163934 | 0.83 | ALDH1A1 (0.55) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL1012515 | 0.83 | KDM4E (0.55) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL23757924 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL7452382 | 0.82 | KDM4E (0.56) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL267612 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL13740239 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KDM4EHSD17B10MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12594277-B2 | Macrocyclic ULK1/2 inhibitors | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2026-04-07 | — | — | US | disclosed |
| US-20230099804-A1 | MACROCYCLIC ULK1/2 INHIBITORS | Sanford Burnham Prebys Medical Discovery Institute | 2023-03-30 | — | — | US | disclosed |
| CN-115515588-A | Macrocyclic ULK1/2 inhibitors | 萨克生物研究学院 | 2022-12-23 | — | — | CN | disclosed |
| EP-4103183-A1 | MACROCYCLIC ULK1/2 INHIBITORS | Salk Institute for Biological Studies (US) | 2022-12-21 | — | — | EP | disclosed |
| WO-2021163627-A1 | MACROCYCLIC ULK1/2 INHIBITORS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2021-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12594277-B2 | Macrocyclic ULK1/2 inhibitors | ULK1, ULK2, ULK3 | ALDH1A1 4428/4885KDM4E 2260/4885HSD17B10 2971/4885 |
| US-20230099804-A1 | MACROCYCLIC ULK1/2 INHIBITORS | ULK1, ULK2, ULK3 | ALDH1A1 4090/4885KDM4E 2324/4885HSD17B10 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.