Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23758261 | 0.94 | RAB9A (0.61) | GSK3BNPC1RAB9AMEN1KMT2A | |
| SCHEMBL23758265 | 0.90 | RAB9A (0.59) | GSK3BNPC1RAB9AMEN1KMT2A | |
| SCHEMBL23758257 | 0.90 | KMT2A (0.57) | NPC1RAB9AMEN1KMT2ATP53 | |
| SCHEMBL23758264 | 0.89 | RAB9A (0.64) | GSK3BNPC1RAB9AMEN1KMT2A | |
| SCHEMBL23758263 | 0.86 | ADORA3 (0.55) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL31679102 | 0.85 | ADORA3 (0.54) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL23758256 | 0.83 | ADORA3 (0.63) | GSK3BNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7135272 | 0.83 | PDGFRB (0.47) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL26464174 | 0.83 | PDGFRB (0.47) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL2121351 | 0.81 | NPC1 (0.83) | GSK3BNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11090289-B2 | Compositions and methods for blocking sodium channels | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11090289-B2 | Compositions and methods for blocking sodium channels | SCN3A, SCN1B, SCN2B | GSK3B 386/4885NPC1 483/4885RAB9A 2068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.