Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 6/20 | 0.69 |
| ▸ | EGFR | P00533 | 3/20 | 0.69 |
| ▸ | FADS1 | O60427 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | PIP4K2A | P48426 | 4/20 | 0.63 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.58 |
| ▸ | RAF1 | P04049 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923033 | 0.85 | PIP4K2A (0.73) | MEN1KMT2ARAB9AEGFRFADS1 | |
| SCHEMBL16363310 | 0.84 | KMT2A (0.73) | MEN1KMT2ARAB9AEGFRFADS1 | |
| SCHEMBL4738626 | 0.82 | FADS1 (1.00) | MEN1KMT2ARAB9AEGFRFADS1 | |
| SCHEMBL810888 | 0.82 | EGFR (1.00) | MEN1KMT2ARAB9AEGFRFADS1 | |
| Hydrochloric Acid SCHEMBL6836391 | 0.81 | EGFR (0.97) | MEN1KMT2ARAB9AEGFRFADS1 | |
| SCHEMBL9431935 | 0.78 | KMT2A (0.54) | MEN1KMT2ARAB9AEGFRFADS1 | |
| SCHEMBL3799139 | 0.78 | MEN1 (0.54) | MEN1KMT2ARAB9AEGFRFADS1 | |
| SCHEMBL30827872 | 0.78 | PIP4K2A (0.64) | MEN1KMT2ARAB9AEGFRFADS1 | |
| SCHEMBL3395499 | 0.77 | RAB9A (0.70) | MEN1KMT2ARAB9AEGFRNPC1 | |
| SCHEMBL5315096 | 0.76 | RAB9A (0.79) | MEN1KMT2ARAB9AEGFRFADS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249155-B2 | Thieno [2, 3-D] pyrimidine derivatives and their use to treat arrhythmia | XENTION LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |
| EP-2694518-B1 | THIENO[2,3-D]PYRIMIDINE DERIVATIVES AND THEIR USE TO TREAT ARRHYTHMIA | XENTION LTD (GB) | 2015-10-07 | — | — | EP | disclosed |
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| US-20050026935-A1 | Compounds | XENTION DISCOVERY LTD. | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026935-A1 | Compounds | KCNJ11, KCNJ1, KCNH1 | MEN1 265/4885KMT2A 1857/4885RAB9A 1622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.