Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL502853 | 0.75 | KCNMA1 (0.67) | SLC9A1TSHRSMN1; SMN2KMT2ACASP3 | |
| SCHEMBL21668428 | 0.72 | KCNMA1 (0.47) | SLC9A1TSHRSMN1; SMN2KMT2ACASP3 | |
| SCHEMBL27614744 | 0.72 | KCNMA1 (0.41) | SLC9A1TSHRSMN1; SMN2KMT2ACASP3 | |
| SCHEMBL16856689 | 0.70 | KCNMA1 (0.48) | SLC9A1TSHRSMN1; SMN2KMT2AKCNMA1 | |
| SCHEMBL26227380 | 0.70 | MAPT (0.51) | SLC9A1TSHRSMN1; SMN2KMT2ACASP3 | |
| SCHEMBL23783887 | 0.70 | GRM2 (0.43) | SLC9A1TSHRSMN1; SMN2KMT2ACASP3 | |
| SCHEMBL21512532 | 0.69 | KCNMA1 (0.50) | SLC9A1TSHRSMN1; SMN2KMT2ACASP3 | |
| SCHEMBL15426146 | 0.68 | PKM (0.55) | SMN1; SMN2KMT2AKCNMA1TDP1KCNH2 | |
| SCHEMBL812320 | 0.68 | SMN1; SMN2 (0.43) | SLC9A1TSHRSMN1; SMN2KMT2AKCNMA1 | |
| SCHEMBL3977744 | 0.68 | TDP1 (0.56) | SLC9A1SMN1; SMN2KMT2AKCNMA1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |