Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 17/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30746067 | 1.00 | RET (0.41) | RETPIK3CDLRRK2GPR119 | |
| SCHEMBL23763271 | 0.83 | GPR119 (0.43) | GPR119 | |
| SCHEMBL30746064 | 0.82 | CYP11B2 (0.38) | PIK3CDGPR119 | |
| SCHEMBL23763270 | 0.82 | CYP11B2 (0.38) | PIK3CDGPR119 | |
| SCHEMBL23763418 | 0.81 | MAP3K12 (0.41) | RETLRRK2 | |
| SCHEMBL29968218 | 0.81 | MAP3K12 (0.41) | RETLRRK2 | |
| SCHEMBL23763268 | 0.73 | CCNC (0.46) | RETGPR119 | |
| SCHEMBL29968457 | 0.73 | PIK3CD (0.47) | RETPIK3CD | |
| SCHEMBL23763432 | 0.73 | PIK3CD (0.47) | RETPIK3CD | |
| SCHEMBL29968589 | 0.69 | MAP3K12 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159993-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE (IRAK) /FMS-LIKE RECEPTOR TYROSINE KINASE (FLT3), PHARMACEUTICAL PRODUCTS THEREOF, AND METHODS THEREOF | PHARMABLOCK SCIENCES (NANJING) , INC. (CN) | 2021-08-19 | — | — | WO | disclosed |