Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 5/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30746064 | 1.00 | CYP11B2 (0.38) | CYP11B2ACACBUSP30SCD5JAK2 | |
| SCHEMBL23763271 | 0.89 | GPR119 (0.43) | CYP11B2ACACBUSP30SCD5JAK2 | |
| SCHEMBL30746067 | 0.82 | RET (0.41) | GPR119PIK3CD | |
| SCHEMBL23763183 | 0.82 | RET (0.41) | GPR119PIK3CD | |
| SCHEMBL30327758 | 0.73 | CYP11B2 (0.45) | CYP11B2ACACBSCD5GPR183HDAC2 | |
| SCHEMBL1604637 | 0.73 | USP2 (0.44) | CYP11B2ACACBUSP30SCD5GPR183 | |
| SCHEMBL23763095 | 0.71 | ALDH1A1 (0.52) | — | |
| SCHEMBL29968245 | 0.71 | ALDH1A1 (0.52) | — | |
| SCHEMBL20898976 | 0.69 | GPR119 (0.46) | CYP11B2ACACBSCD5GPR119EIF2AK4 | |
| SCHEMBL31283429 | 0.69 | POLB (0.40) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159993-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE (IRAK) /FMS-LIKE RECEPTOR TYROSINE KINASE (FLT3), PHARMACEUTICAL PRODUCTS THEREOF, AND METHODS THEREOF | PHARMABLOCK SCIENCES (NANJING) , INC. (CN) | 2021-08-19 | — | — | WO | disclosed |