SCHEMBL23763584

SCHEMBL23763584

Cc1cc(C)c(-c2cccc3c2c2c4c5c(c6c(-c7c(C)cc(C)cc7C)cccc6n5c5nc6ccccc6n45)c4c2n3c2nc3ccccc3n42)c(C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.39
TP53 P04637 4/20 0.39
PDE10A Q9Y233 6/20 0.37
PDE2A O00408 5/20 0.37
FLT3 P36888 1/20 0.37
GAA P10253 2/20 0.36
HPGD P15428 2/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
LCK P06239 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34
KDM4E B2RXH2 3/20 0.34
POLB P06746 2/20 0.34
ALDH1A1 P00352 2/20 0.34
LMNA P02545 1/20 0.34
HSD17B10 Q99714 1/20 0.34
MEN1 O00255 1/20 0.34
MAPK1 P28482 1/20 0.34
KMT2A Q03164 1/20 0.34
GLA P06280 1/20 0.34
XBP1 P17861 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23763583 0.81 FLT3 (0.32) MAPTTP53FLT3
SCHEMBL23763634 0.78 MAPT (0.38) MAPTTP53FLT3GAAHPGD
SCHEMBL23763392 0.78 HPGD (0.39) MAPTTP53FLT3GAAHPGD
SCHEMBL23763393 0.77 MAPT (0.40) MAPTTP53PDE10APDE2AFLT3
SCHEMBL23763563 0.76 CRHR1 (0.41) MAPTPDE10APDE2AFLT3GAA
SCHEMBL22062530 0.75 TP53 (0.41) MAPTTP53PDE10APDE2AFLT3
SCHEMBL24601592 0.73 CYP1A2 (0.38) MAPTFLT3HPGDSMN1; SMN2KDM4E
SCHEMBL23763632 0.72 SRC (0.38) MAPTTP53FLT3GAAHPGD
SCHEMBL22063055 0.71 SMN1; SMN2 (0.43) MAPTTP53PDE10AGAAHPGD
SCHEMBL23763633 0.71 ALDH1A1 (0.40) MAPTTP53PDE10APDE2AFLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3865486-A1 HETEROCYCLIC COMPOUND AND AN ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE HETEROCYCLIC COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2021-08-18 EP disclosed