Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9431625 | 0.77 | CHRNA7 (0.49) | CHRNA7TLR7 | |
| SCHEMBL9459255 | 0.74 | CHRNA7 (0.53) | CHRNA7 | |
| SCHEMBL15805581 | 0.72 | MBOAT4 (0.43) | CHRNA7TLR7 | |
| SCHEMBL15150043 | 0.71 | KDM1A (0.51) | — | |
| SCHEMBL22502996 | 0.71 | QDPR (0.45) | TLR7 | |
| SCHEMBL6628801 | 0.70 | CHRNA7 (0.66) | CHRNA7 | |
| SCHEMBL20847695 | 0.69 | KDM4E (0.47) | CHRNA7 | |
| SCHEMBL24501504 | 0.69 | KDM4E (0.44) | CHRNA7 | |
| SCHEMBL1538393 | 0.69 | ALDH1A1 (0.54) | CHRNA7 | |
| SCHEMBL9430901 | 0.68 | CHRNB2 (0.49) | CHRNA7TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3450433-B1 | PURINE DERIVATIVES AS TLR7 INHIBITORS FOR TREATING E.G. SYSTEMIC LUPUS ERYTHEMATOSUS | SUMITOMO DAINIPPON PHARMA CO LTD (JP) | 2021-08-18 | — | — | EP | disclosed |