Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753737 | 0.87 | JAK1 (0.53) | JAK1TYK2JAK2SMN1; SMN2TP53 | |
| SCHEMBL23754392 | 0.82 | JAK2 (0.51) | JAK1TYK2JAK2SMN1; SMN2TP53 | |
| SCHEMBL23754203 | 0.81 | JAK2 (0.47) | JAK1TYK2JAK2SMN1; SMN2TP53 | |
| SCHEMBL23754207 | 0.78 | JAK1 (0.51) | JAK1TYK2JAK2SMN1; SMN2TP53 | |
| SCHEMBL23754239 | 0.77 | SMN1; SMN2 (0.46) | JAK1SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL23764043 | 0.73 | JAK1 (0.42) | JAK1JAK2SMN1; SMN2TP53MAPT | |
| SCHEMBL23754210 | 0.72 | MAPT (0.46) | JAK1SMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL23764045 | 0.71 | IL2 (0.52) | JAK1TYK2JAK2SMN1; SMN2TP53 | |
| SCHEMBL2250300 | 0.66 | NUDT1 (0.73) | JAK1TYK2JAK2TP53NPC1 | |
| SCHEMBL2252969 | 0.66 | EGLN2 (0.54) | JAK1TYK2JAK2NPC1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021161084-A1 | N-(4-FLUOROPHENYL)-5-PHENYL-[1,2,4] TRIAZOLO [1,5-A] PYRIDINE-2-CARBOXAMIDE DERIVATIVES AND THEIR SYNTHESIS THEREOF | NINGEGOWDA RAGHU (IN) | 2021-08-19 | — | — | WO | disclosed |