Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 3/20 | 0.48 |
| ▸ | ASPH | Q12797 | 1/20 | 0.45 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770410 | 0.91 | ALDH1A1 (0.46) | CNR1CNR2ASPHKDM8MAPK14 | |
| SCHEMBL23770108 | 0.81 | ALDH1A1 (0.56) | KDM4EALDH1A1GAANPC1LMNA | |
| SCHEMBL23770089 | 0.81 | KMT2A (0.49) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL30619454 | 0.81 | HPGD (0.44) | CNR1CNR2KDM4EALDH1A1GAA | |
| SCHEMBL23203419 | 0.81 | HPGD (0.44) | CNR1CNR2KDM4EALDH1A1GAA | |
| SCHEMBL23770322 | 0.80 | TTK (0.45) | ASPHKDM8MAPK14KDM4EGRIN2B | |
| SCHEMBL23770069 | 0.79 | ALDH1A1 (0.40) | CNR1CNR2KDM4EALDH1A1GAA | |
| SCHEMBL23770114 | 0.79 | ALDH1A1 (0.53) | KDM4EALDH1A1GAANPC1LMNA | |
| SCHEMBL23770352 | 0.79 | CNR1 (0.41) | CNR1CNR2KDM4EALDH1A1GAA | |
| SCHEMBL31659140 | 0.79 | ALDH1A1 (0.40) | CNR1CNR2KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | THE GENERAL HOSPITAL CORPORATION (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | THE GENERAL HOSPITAL CORPORATION (US) | 2023-07-25 | — | — | US | disclosed |
| US-20210253558-A1 | Inhibitors of Prolyl-tRNA-Synthetase | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | GARS1, AARS1, NSUN3 | CNR1 4417/4885CNR2 4645/4885ASPH 522/4885 |
| US-20210253558-A1 | Inhibitors of Prolyl-tRNA-Synthetase | GARS1, AARS1, TRMT1 | CNR1 4533/4885CNR2 4707/4885ASPH 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.