Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770319 | 0.86 | KMT2A (0.44) | KMT2A | |
| SCHEMBL26612401 | 0.81 | MAPT (0.44) | TTKMAPK14KMT2AKDM4EWNT1 | |
| SCHEMBL23770109 | 0.81 | NPC1 (0.46) | WNT1DYRK1AGRM7MAPTNPC1 | |
| SCHEMBL23770087 | 0.80 | CNR1 (0.48) | TTKMAPK14KDM4EASPHKDM8 | |
| SCHEMBL23770107 | 0.80 | NPC1 (0.44) | KMT2AWNT1DYRK1AGRM7NPC1 | |
| SCHEMBL23770077 | 0.80 | ABCC1 (0.43) | WNT1DYRK1AGRM7NPC1LMNA | |
| SCHEMBL23770333 | 0.79 | KDM4E (0.48) | KMT2AKDM4EWNT1DYRK1AGRM7 | |
| SCHEMBL23770104 | 0.79 | CHRM4 (0.41) | KDM4EWNT1DYRK1AGRM7MAPT | |
| SCHEMBL31659148 | 0.79 | CHRM4 (0.41) | KDM4EWNT1DYRK1AGRM7MAPT | |
| SCHEMBL23770102 | 0.78 | RAB9A (0.47) | KMT2AKDM4EGRM7NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | THE GENERAL HOSPITAL CORPORATION (US) | 2023-07-25 | — | — | US | disclosed |
| US-20210253558-A1 | Inhibitors of Prolyl-tRNA-Synthetase | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708353-B2 | Inhibitors of prolyl-tRNA-synthetase | GARS1, AARS1, NSUN3 | TTK 4216/4885MAPK14 4319/4885KMT2A 2505/4885 |
| US-20210253558-A1 | Inhibitors of Prolyl-tRNA-Synthetase | GARS1, AARS1, TRMT1 | TTK 3530/4885MAPK14 4446/4885KMT2A 2345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.