Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | EIF4E | P06730 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925191 | 0.77 | SCN9A (0.53) | SCN9AEGLN2 | |
| SCHEMBL29464395 | 0.77 | SCN9A (0.53) | SCN9AEGLN2 | |
| SCHEMBL23770430 | 0.71 | ABL1 (0.33) | KCNH2EGLN2MAP4K1CDC7CDK2 | |
| SCHEMBL23770611 | 0.71 | EGLN2 (0.36) | SCN9AKCNH2EGLN2MAP4K1HSP90AB1 | |
| SCHEMBL19951268 | 0.70 | SCN9A (0.45) | SCN9A | |
| SCHEMBL19951427 | 0.69 | HSD11B1 (0.46) | SCN9AEGLN2HSP90AB1 | |
| SCHEMBL3362493 | 0.68 | EGLN2 (0.44) | EGLN2MAP4K1HSP90AB1MAP3K14EIF4E | |
| SCHEMBL3361910 | 0.67 | CYP11B2 (0.42) | SCN9AKCNH2EGLN2EIF4E | |
| SCHEMBL3366217 | 0.67 | KCNH2 (0.52) | KCNH2EGLN2CDC7CDK2GSK3B | |
| SCHEMBL23770442 | 0.65 | EGLN2 (0.38) | KCNH2EGLN2CDC7CDK2EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |