Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | CTSC | P53634 | 1/20 | 0.32 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770707 | 0.92 | AGPAT2 (0.39) | IL2BACE1PDE2AAGPAT2MCL1 | |
| SCHEMBL23770627 | 0.87 | ADORA2A (0.40) | KDM1ACTSCCTSSDPP4NPSR1 | |
| SCHEMBL23770626 | 0.87 | TRPV1 (0.35) | CTSCAGPAT2DPP4 | |
| SCHEMBL23770756 | 0.83 | BACE1 (0.36) | BACE1DPP4 | |
| SCHEMBL23770409 | 0.83 | BACE1 (0.35) | BACE1DPP4 | |
| SCHEMBL23770542 | 0.81 | MPL (0.34) | BACE1 | |
| SCHEMBL23770554 | 0.80 | DPP4 (0.33) | DPP4 | |
| SCHEMBL23770415 | 0.80 | ADORA2A (0.34) | BACE1DPP4MAPT | |
| SCHEMBL23770614 | 0.80 | PTPN1 (0.30) | — | |
| SCHEMBL23770569 | 0.79 | EPAS1 (0.34) | BACE1EPAS1CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |