Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.32 |
| ▸ | CDK9 | P50750 | 3/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770677 | 0.85 | ABL1 (0.36) | CCNT1CDK9SMOABL1 | |
| SCHEMBL23770850 | 0.85 | LRRK2 (0.33) | LRRK2ABL1 | |
| SCHEMBL19951388 | 0.82 | GHSR (0.39) | KRASLRRK2ABL1SCN9A | |
| SCHEMBL23770699 | 0.80 | ATR (0.45) | — | |
| SCHEMBL23770798 | 0.76 | ITGB2 (0.38) | LRRK2 | |
| SCHEMBL19925066 | 0.74 | GHSR (0.39) | LRRK2ABL1 | |
| SCHEMBL23770583 | 0.73 | RAF1 (0.36) | HCRTR1HCRTR2LRRK2ABL1 | |
| SCHEMBL23770836 | 0.73 | MPL (0.33) | HCRTR1HCRTR2LRRK2 | |
| SCHEMBL23770741 | 0.73 | ABL1 (0.35) | CCNT1CDK9LRRK2SMOABL1 | |
| SCHEMBL23770724 | 0.71 | MAP4K1 (0.34) | TYK2CCNT1CDK9SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |