Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.32 |
| ▸ | BRAF | P15056 | 3/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770583 | 0.88 | RAF1 (0.36) | ABL1RAF1BRAF | |
| SCHEMBL23770587 | 0.86 | ABL1 (0.39) | ABL1CCNT1CDK9 | |
| SCHEMBL23770570 | 0.85 | KRAS (0.33) | ABL1CCNT1CDK9SMO | |
| SCHEMBL23770741 | 0.84 | ABL1 (0.35) | ABL1RAF1BRAFCCNT1CDK9 | |
| SCHEMBL19951398 | 0.82 | ABL1 (0.37) | ABL1SMO | |
| SCHEMBL23770776 | 0.81 | ABL1 (0.38) | ABL1CCNT1CDK9 | |
| SCHEMBL23770615 | 0.80 | ATR (0.43) | RAF1BRAF | |
| SCHEMBL23770447 | 0.75 | SOS1 (0.34) | ABL1RAF1BRAF | |
| SCHEMBL19925201 | 0.74 | GHSR (0.38) | ABL1RAF1BRAFSMO | |
| SCHEMBL29464868 | 0.74 | GHSR (0.38) | ABL1RAF1BRAFSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |