Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.36 |
| ▸ | BRAF | P15056 | 10/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.34 |
| ▸ | ITGAL | P20701 | 4/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770677 | 0.88 | ABL1 (0.36) | RAF1BRAFABL1 | |
| SCHEMBL23770447 | 0.87 | SOS1 (0.34) | RAF1BRAFABL1SOS1 | |
| SCHEMBL23770596 | 0.86 | ADRB1 (0.41) | RAF1BRAFABL1SOS1 | |
| SCHEMBL23770798 | 0.86 | ITGB2 (0.38) | ITGB2ICAM1ITGALSOS1CLK2 | |
| SCHEMBL19951397 | 0.82 | RAF1 (0.37) | RAF1BRAFABL1 | |
| SCHEMBL23770773 | 0.82 | ABL1 (0.37) | ABL1 | |
| SCHEMBL23770607 | 0.81 | JAK2 (0.35) | ABL1LRRK2 | |
| SCHEMBL23770701 | 0.80 | ATR (0.42) | RAF1BRAF | |
| SCHEMBL23770431 | 0.75 | GHSR (0.36) | — | |
| SCHEMBL23770744 | 0.75 | RAF1 (0.33) | RAF1BRAFABL1SOS1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |