Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 5/20 | 0.36 |
| ▸ | CCNK | O75909 | 4/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | CDK9 | P50750 | 4/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770706 | 0.97 | SMN1; SMN2 (0.36) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL23770617 | 0.92 | CYP1A2 (0.39) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL19970024 | 0.90 | MAPK3 (0.38) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL19970021 | 0.90 | MAPK3 (0.38) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL19970019 | 0.90 | MAPK3 (0.38) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL23770790 | 0.89 | IL1B (0.32) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL23770784 | 0.89 | SYK (0.38) | CCNT1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL19970087 | 0.86 | CCNT1 (0.35) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL23770848 | 0.85 | IL1B (0.33) | IL1BTNF | |
| SCHEMBL23770815 | 0.85 | CYP1A2 (0.39) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |