Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | IL1B | P01584 | 1/20 | 0.31 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19970087 | 0.96 | CCNT1 (0.35) | SYKVCPRORCHSD11B1EPHX2 | |
| SCHEMBL19970024 | 0.91 | MAPK3 (0.38) | SYKEPHX2TSHRNUDT1IL1B | |
| SCHEMBL19970021 | 0.91 | MAPK3 (0.38) | SYKEPHX2TSHRNUDT1IL1B | |
| SCHEMBL19970019 | 0.91 | MAPK3 (0.38) | SYKEPHX2TSHRNUDT1IL1B | |
| SCHEMBL19951335 | 0.89 | SYK (0.42) | SYKVCPRORCHSD11B1EPHX2 | |
| SCHEMBL23770573 | 0.89 | CCNT1 (0.36) | CYP1A2CYP3A4CYP2D6TSHRCLK4 | |
| SCHEMBL23770706 | 0.88 | SMN1; SMN2 (0.36) | TSHRMEN1KMT2ACCNT1 | |
| SCHEMBL23770848 | 0.86 | IL1B (0.33) | IL1BCTSA | |
| SCHEMBL23770617 | 0.86 | CYP1A2 (0.39) | SYKCYP1A2CYP3A4CYP2D6MEN1 | |
| SCHEMBL23770790 | 0.85 | IL1B (0.32) | IL1BCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |