Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770769 | 0.86 | ALDH1A1 (0.38) | — | |
| SCHEMBL23770756 | 0.84 | BACE1 (0.36) | MPLSCN9ATRPA1CYP3A4CYP2D6 | |
| SCHEMBL23770409 | 0.83 | BACE1 (0.35) | SCN10ASCN9ASCN5ASCN2ASCN3A | |
| SCHEMBL23770415 | 0.82 | ADORA2A (0.34) | MPLPOLB | |
| SCHEMBL23770614 | 0.82 | PTPN1 (0.30) | — | |
| SCHEMBL23770590 | 0.81 | ADORA2A (0.35) | — | |
| SCHEMBL23770624 | 0.80 | — | — | |
| SCHEMBL23770605 | 0.80 | — | — | |
| SCHEMBL23770542 | 0.79 | MPL (0.34) | MPL | |
| SCHEMBL29464469 | 0.78 | SCN10A (0.39) | SCN10AMPLSCN9ASCN5ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |