Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | CTSA | P10619 | 2/20 | 0.37 |
| ▸ | AGPAT2 | O15120 | 6/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770769 | 0.89 | ALDH1A1 (0.38) | AGPAT2HSP90AA1HSP90AB1 | |
| SCHEMBL23770558 | 0.87 | AGPAT2 (0.40) | CTSAAGPAT2 | |
| SCHEMBL23770715 | 0.85 | AGPAT2 (0.34) | CTSAAGPAT2CCNT1HSP90AB1 | |
| SCHEMBL23770554 | 0.85 | DPP4 (0.33) | CCNT1CDK9 | |
| SCHEMBL23770412 | 0.82 | CCNT1 (0.34) | CCNT1CDK9 | |
| SCHEMBL23770414 | 0.80 | ALOX5AP (0.34) | CCNT1CDK9 | |
| SCHEMBL19968777 | 0.79 | SCN9A (0.42) | CTSASCN9ANR3C1PGR | |
| SCHEMBL29464327 | 0.79 | SCN9A (0.42) | CTSASCN9ANR3C1PGR | |
| SCHEMBL23770546 | 0.79 | — | — | |
| SCHEMBL23770415 | 0.79 | ADORA2A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |